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Reliability of Examination Findings in Suspected Community-Acquired Pneumonia
Todd A Florin1,2, Lilliam Ambroggio2,3,4, Cole Brokamp3
1Divisions of Emergency Medicine, todd.florin@cchmc.org.
Insights
Physical examination findings for diagnosing pediatric community-acquired pneumonia (CAP) show limited reliability. Only wheezing, retractions, and respiratory rate demonstrated acceptable agreement between clinicians.
Area of Science:
- Pediatric Pulmonology
- Clinical Diagnostics
- Medical Research Methodology
Background:
- National guidelines recommend history and physical exam for diagnosing pediatric community-acquired pneumonia (CAP).
- Limited data exists on the consistency of physical examination findings among clinicians for suspected CAP in children.
Purpose of the Study:
- To evaluate the interrater reliability of physical examination findings used in diagnosing CAP in outpatient children.
- To identify specific examination findings with acceptable reliability for clinical use.
Main Methods:
- Prospective cohort study of children (3 months–18 years) with suspected CAP from July 2013 to May 2016.
- Two independent clinicians assessed children using identical forms; reliability assessed using Fleiss' kappa and intraclass correlation coefficient.
- Chest radiograph was performed; specific exclusion criteria applied.
Main Results:
- No examination finding achieved substantial agreement (κ/ICC > 0.8).
- Wheezing and retractions showed moderate to substantial agreement (κ/ICC = 0.6–0.8).
- Only wheezing, retractions, and respiratory rate had acceptable agreement (lower 95% CI >0.4).
Conclusions:
- Many physical examination findings used for pediatric CAP diagnosis exhibit only fair to moderate reliability.
- Clinical management and research of pediatric CAP should consider the limited reliability of most examination findings.
- Further research may be needed to refine diagnostic criteria or improve examination consistency.
Background:
The authors of national guidelines emphasize the use of history and examination findings to diagnose community-acquired pneumonia (CAP) in outpatient children. Little is known about the interrater reliability of the physical examination in children with suspected CAP.
Methods:
This was a prospective cohort study of children with suspected CAP presenting to a pediatric emergency department from July 2013 to May 2016. Children aged 3 months to 18 years with lower respiratory signs or symptoms who received a chest radiograph were included. We excluded children hospitalized ≤14 days before the study visit and those with a chronic medical condition or aspiration. Two clinicians performed independent examinations and completed identical forms reporting examination findings. Interrater reliability for each finding was reported by using Fleiss' kappa (κ) for categorical variables and intraclass correlation coefficient (ICC) for continuous variables.
Results:
No examination finding had substantial agreement (κ/ICC > 0.8). Two findings (retractions, wheezing) had moderate to substantial agreement (κ/ICC = 0.6-0.8). Nine findings (abdominal pain, pleuritic pain, nasal flaring, skin color, overall impression, cool extremities, tachypnea, respiratory rate, and crackles/rales) had fair to moderate agreement (κ/ICC = 0.4-0.6). Eight findings (capillary refill time, cough, rhonchi, head bobbing, behavior, grunting, general appearance, and decreased breath sounds) had poor to fair reliability (κ/ICC = 0-0.4). Only 3 examination findings had acceptable agreement, with the lower 95% confidence limit >0.4: wheezing, retractions, and respiratory rate.
Conclusions:
In this study, we found fair to moderate reliability of many findings used to diagnose CAP. Only 3 findings had acceptable levels of reliability. These findings must be considered in the clinical management and research of pediatric CAP.
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