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Microsomal vinyl oxide synthetase: modification of its kinetic parameters by chemical carcinogens
Archives of Toxicology. Supplement. = Archiv Fur Toxikologie. Supplement
|January 1, 1979
Abstract:
The kinetic parameters of liver microsomal vinyl oxide synthetase as well as their modifications under the influence of various pretreatments have been evaluated, using 1,1,2-trichlorethylene (TCE) as a substrate. The results were correlated with those obtained using aldrin oxide synthetase and benzpyrene hydroxylase as typical cytochrome P-450 dependent enzymatic activity. The treatments of animals with chemical carcinogens selectively increase the affinity of those enzymes for their substrates.