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Related Concept Videos

Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

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Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
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Somatosensation01:33

Somatosensation

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The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Major Somatic Sensory Pathways01:28

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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What is a Sensory System?01:31

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Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position.
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Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

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The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
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Introduction to Special Senses01:26

Introduction to Special Senses

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Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
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Related Experiment Video

Updated: Feb 24, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
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Sensory Neuronopathies.

Allison Crowell1, Kelly G Gwathmey2

  • 1Department of Neurology, University of Virginia, P.O. Box 800394, Charlottesville, VA, 22908, USA.

Current Neurology and Neuroscience Reports
|August 25, 2017
PubMed
Summary
This summary is machine-generated.

Acquired sensory neuronopathies damage sensory ganglia. Early treatment within 2 months of symptom onset offers the best chance for patient improvement, though standard treatments remain undetermined.

Keywords:
Dorsal root ganglionDorsal root ganglionopathyParaneoplastic neuropathySensory neuronopathySjögren’s syndrome

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Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Sensory neuronopathies are a group of sensory-predominant polyneuropathies.
  • These conditions arise from damage to the dorsal root and trigeminal sensory ganglia.

Purpose of the Study:

  • To review the causes of acquired sensory neuronopathies.
  • To outline diagnostic approaches.
  • To discuss current treatment strategies.

Main Methods:

  • Review of recent diagnostic criteria and electrodiagnostic studies.
  • Analysis of the identified treatment window for acquired sensory neuronopathies.

Main Results:

  • Validated diagnostic criteria now exist to differentiate sensory neuronopathies.
  • The optimal treatment window is approximately 8 months, with best outcomes if initiated within 2 months of symptom onset.
  • Progress in characterizing clinical, electrophysiologic, and imaging features has been made.

Conclusions:

  • While diagnostic capabilities have advanced, effective treatments for sensory neuronopathies are still lacking.
  • No randomized controlled trials guide current management, and a standard treatment approach is undetermined.