Bistinospinosides A and B, Dimeric Clerodane Diterpene Glycosides from Tinospora sagittata
Wei Li1, Chao Huang1, Qingbo Liu1
1Faculty of Pharmaceutical Sciences, Toho University , Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
Abstract:
Two dimeric clerodane diterpene glycosides, namely, bistinospinosides A (1) and B (2), were isolated from the roots of Tinospora sagittata. Their structures were elucidated by extensive spectroscopic data interpretation. The compounds feature an unusual 1,4-epoxycyclohexane ring in their structures and may be biosynthetically constructed via an intermolecular Diels-Alder [4+2] cycloaddition from the corresponding clerodane diterpene. The compounds were evaluated in a nitric oxide inhibitory assay using J774.1 macrophage-like cells.
More Related Videos
Related Concept Videos
Bacterial Phylum Spirochaetes
Drugs that Stabilize Microtubules
Drugs that Destabilize Microtubules
Bacterial Phylum Tenericutes
Spasmolytic Agents: Chemical Classification
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also...
Cytoskeletal Proteins in Bacteria


