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Updated: Feb 24, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Future of transcatheter aortic valve implantation - evolving clinical indications
Rishi Puri1, Chekrallah Chamandi2, Tania Rodriguez-Gabella2
1Québec Heart & Lung Institute, Laval University, 2725 Chemin Ste-Foy, Québec City, Québec G1V 4G5, Canada; at the Cleveland Clinic Coordinating Center for Clinical Research (C5R), 9500 Euclid Avenue, Cleveland, Ohio 44195, USA; and at the Department of Medicine, University of Adelaide, North Terrace Campus, Adelaide, South Australia 5005, Australia.
Abstract:
Accumulating clinical experience and technological improvements have provided the basis for transcatheter aortic valve implantation (TAVI) to emerge as a well-established means for treating patients with severe symptomatic aortic stenosis at high or prohibitive surgical risk. During this decade, TAVI has emerged as a valid alternative to surgical aortic valve replacement in patients at intermediate surgical risk, and several studies are currently being performed to evaluate the role of TAVI in patients at low surgical risk. Furthermore, promising, but preliminary, data are emerging on the efficacy of TAVI for treating patients with bicuspid aortic valve disease, as well as patients with pure aortic regurgitation. In this Perspectives article, we summarize the evolving indications for TAVI, and give our opinion on the future perspectives for this procedure.
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