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    This editorial explores flexible, trans-diagnostic treatments beyond branded therapies. It highlights the need for empirically identified mechanisms and reviews studies on child stress response and digital therapies.

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    Area of Science:

    • Child and Adolescent Psychiatry
    • Developmental Neuroscience
    • Clinical Psychology

    Background:

    • The editorial advocates for trans-diagnostic and modular treatment approaches, moving beyond rigid, branded therapies.
    • It emphasizes the necessity of empirically identified trans-diagnostic target mechanisms for rigorous intervention science.
    • Advances in basic science and personalized medicine necessitate more flexible therapeutic frameworks.

    Discussion:

    • Reviews two studies investigating potential trans-diagnostic mechanisms in the developmental neurobiology of stress response in children.
    • Examines treatment trials utilizing digitally-aided therapy, noting challenges with sustained adherence.
    • Discusses an independent investigation of an autism screening instrument, proposing enhancements for specificity.

    Key Insights:

    • Trans-diagnostic mechanisms in child stress response are crucial for developing flexible and personalized therapies.
    • Digitally-aided therapies show promise but face adherence challenges.
    • Improving the specificity of autism screening instruments is essential for accurate diagnosis.

    Outlook:

    • Future research should focus on identifying and validating trans-diagnostic mechanisms for targeted interventions.
    • Strategies to enhance adherence to digital mental health interventions are needed.
    • Continued refinement of diagnostic and screening tools, like autism assessments, will improve clinical outcomes.