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Uric acid and incident chronic kidney disease in dyslipidemic individuals

Fotios Barkas1, Moses Elisaf1, Evangelos Liberopoulos1

  • 1a Department of Internal Medicine, School of Medicine , University of Ioannina , Ioannina , Greece.

Current Medical Research and Opinion
|August 25, 2017
PubMed

Insights

Elevated uric acid (UA) is linked to a higher risk of developing chronic kidney disease (CKD) in patients with dyslipidemia. This association holds even when patients receive comprehensive, multifactorial treatment.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Disorders

Background:

  • Elevated uric acid (UA) is a known risk factor for chronic kidney disease (CKD).
  • The association between UA and CKD in dyslipidemic patients undergoing multifactorial treatment requires further investigation.

Purpose of the Study:

  • To examine the correlation between uric acid levels and the incidence of CKD.
  • To assess this association in a cohort of dyslipidemic individuals receiving multifactorial treatment.

Main Methods:

  • An observational study included 1,095 dyslipidemic patients followed for a median of 6 years.
  • Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate (eGFR) ≤60 mL/min/1.73 m².
  • Multivariate analysis adjusted for confounding factors, including age, gender, diabetes, cardiovascular disease, and lipid-lowering treatments.

Main Results:

  • Higher baseline uric acid (UA) levels were significantly associated with an increased risk of incident CKD (HR=1.26, p=0.001).
  • Patients with UA ≥6 mg/dL had a doubled risk of developing CKD compared to those in the lowest UA quartile (HR=2.01, p=0.02).
  • Other significant risk factors included female gender, older age, diabetes, cardiovascular disease, and lower baseline eGFR.

Conclusions:

  • Higher uric acid levels correlate with an increased risk of incident CKD in dyslipidemic patients.
  • These findings emphasize the importance of monitoring UA levels in this patient population.
  • Managing UA may be a crucial component of multifactorial treatment strategies for dyslipidemia to prevent CKD progression.
Abstract

Keywords:
Uric acidchronic kidney diseasehyperuricemiaincidenceriskstatins

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