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Updated: Feb 24, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Can ovarian double-stimulation in the same menstrual cycle improve IVF outcomes?
Maria Cecília de Almeida Cardoso1, Alessandra Evangelista1,2, Cássio Sartório1
1Vida - Centro de Fertilidade, Rio de Janeiro, Brazil.
Objective:
To evaluate the double-stimulation protocol efficacy over conventional ovarian stimulation in recovering a more adequate number of oocytes and increase the number of embryos to be transferred or to be genetically analyzed.
Methods:
A retrospective and comparative study with 13 patients who underwent unsuccessful in vitro fertilization (IVF) cycles with a conventional antagonist ovarian stimulation protocol and repeat the attempt with a double stimulation protocol. The following variables were analyzed: number of oocytes collected, mature oocytes collected, fertilization rate, blastocyst rate, biopsied blastocyst rate and euploidy rate.
Results:
The double stimulation protocol had a significant higher number of oocytes collected (p=0.007) and mature oocytes to be injected (p=0.01). There was no statistically significant difference in fertilization (p=0.78) and blastocyst (p=0.59) rates.
Conclusion:
Double stimulation favors patients who are at risk of incurring several attempts of IVF to achieve pregnancy.
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