Acridone Alkaloids
1University of the Witwatersrand, Johannesburg, South Africa.
The Alkaloids. Chemistry and Biology
|August 26, 2017
Summary
This review details recent advances in acridone alkaloid chemistry and biology, covering their occurrence, synthesis, and diverse bioactivities like anticancer and antimicrobial properties.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Acridone alkaloids are a significant class of natural products with diverse biological activities.
- Previous reviews on acridone alkaloids were published in 2000, necessitating an update.
Purpose of the Study:
- To provide a comprehensive survey of the literature on acridone alkaloids from mid-1999 to 2016.
- To cover developments in their biosynthesis, occurrence, characterization, synthesis, and bioactivity.
Main Methods:
- Literature review of scientific publications from mid-1999 to 2016.
- Categorization of acridone alkaloids into simple, C-prenylated, fused heterocyclic, and dimeric structures.
- Summary of synthetic approaches and reported bioactivities.
Main Results:
- Detailed characterization of known and novel acridone alkaloids from various sources.
- Comprehensive coverage of synthetic strategies for acridone alkaloids and analogs.
- Summary of bioactivities including cytotoxicity, anticancer, antimicrobial, antiparasitic, and enzyme inhibition.
Conclusions:
- Significant progress has been made in the chemistry and biology of acridone alkaloids.
- Acridone alkaloids and their synthetic analogs exhibit promising therapeutic potential.
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