Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Junín virus persistence in mice.

R D Rabinovich, E F Lascano, M C Boxaca

    Acta Virologica
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Newborn mice infected with Junín virus (JV) showed long-term brain persistence. Mild brain inflammation, not antibody levels, correlated with the persistent virus presence in these juvenile survivors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Eosinophilic granuloma; Finding of special crystals.

    Revista de la Asociacion Medica Argentina·2010
    Same author

    Importance of pH in fixing nervous tissue; Artificial creation of Cajal formalin-bromide and formalin-nitrate type fixatives.

    Archivos. Sociedad Argentina de Anatomia Normal y Patologica·2010
    Same author

    Influence of fixative pH on the Argentine coloration of nervous tissue; experiments with formalin-bromide without neutralizing and neutralized.

    Archivos. Sociedad Argentina de Anatomia Normal y Patologica·2010
    Same author

    Viral reactivation and pseudotype production in an in vitro superinfection system with two different strains of HIV-1.

    Archives of virology·2005
    Same author

    Oxytocin and prostaglandins F2alpha and E2 do not enhance HIV antigen production in vitro.

    Archives of virology·2003
    Same author

    Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America.

    Journal of clinical microbiology·2000

    Area of Science:

    • Neurovirology
    • Immunology
    • Infectious Diseases

    Background:

    • Junín virus (JV) causes Argentine hemorrhagic fever, a severe zoonotic disease.
    • Viral persistence in the central nervous system (CNS) is a potential factor in long-term sequelae.
    • Understanding the host-pathogen dynamics in the neonatal CNS is crucial for disease management.

    Purpose of the Study:

    • To investigate the long-term viral persistence of Junín virus (JV) strain XJ in the brains of newborn mice.
    • To determine the correlation between viral presence, neuropathology, and neutralizing antibody titres (NtAb) in surviving mice.

    Main Methods:

    • Intracerebral inoculation of newborn mice with Junín virus (JV) strain XJ.
    • Monitoring of survival and clinical signs.

    Related Experiment Videos

  • Post-mortem analysis of brain tissue for viral RNA detection.
  • Assessment of neuropathological changes (meningoencephalitis/encephalitis).
  • Measurement of Junín virus (JV)-specific neutralizing antibody titres (NtAb).

    • Main Results:

    • Newborn mice surviving intracerebral JV infection exhibited persistent viral presence in the brain up to 140 days post-infection (p.i.).
    • Mild meningoencephalitis or encephalitis was observed in infected mice.
    • Viral persistence in the brain did not correlate with the presence of neutralizing antibody titres (NtAb).

    Conclusions:

    • Junín virus (JV) can establish long-term persistence in the brain of neonatally infected mice.
    • The development of neutralizing antibodies (NtAb) does not necessarily clear the virus from the CNS.
    • Mild neuropathology correlates with viral presence, suggesting ongoing viral activity despite antibody presence.