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Updated: Feb 24, 2026

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
Published on: March 2, 2017
A genetic heritage; the same yet different: A comparative study in twins
Catherine Mas1, Laure Frapier1
1Département d'ODF, UFR Odontologie de Montpellier, 545, avenue du Pr-Jean-Louis-Viala, 34080 Montpellier, France.
Abstract:
Since the 19th century, and in every field of medicine, monozygotic twins have been studied to assess the involvement of genetic and environmental factors in phenotypic expression. The phenotype/genotype relationship remains the leading problem in contemporary biology. In dentofacial orthopedics, this relationship is of relevance in the three-dimensional approach to the face, in both diagnosis and treatment. The present study of two monozygotic twins presenting skeletal class III malocclusions which were genetic yet different is a clear illustration of the interaction of genotype and epigenetic factors with environmental influences. We will demonstrate that treatment can reduce phenotypic differences.
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