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A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms

Xinwen Wang1, Nada Rida1, Jian Shi1

  • 1Department of Clinical Pharmacy (X.W., N.R., J.S., H.-J.Z.) and Cardiovascular Center (A.H.W.), University of Michigan, Ann Arbor, Michigan; and Department of Pharmacy Practice and Administrative Sciences, University of New Mexico, Albuquerque, New Mexico (B.E.B.).

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|August 26, 2017
PubMed
Summary

Genetic variations in Carboxylesterase 1 (CES1) significantly impact drug metabolism. This study identified several CES1 nonsynonymous single nucleotide polymorphisms (nsSNPs) that impair enzyme activity, potentially affecting therapeutic outcomes for patients on CES1-metabolized drugs.

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