Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 24, 2026

Acute Myocardial Infarction in Rats
07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

54.8K

Regional Dysfunction After Myocardial Infarction in Rats.

Emil K S Espe1, Jan Magnus Aronsen2, Morten Eriksen2

  • 1From the Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Norway (E.K.S.E., J.M.A., O.M.S., L.Z., I.S.); Bjørknes College, Oslo, Norway (J.M.A.); and Respinor AS, Oslo, Norway (M.E.). ekespe@medisin.uio.no.

Circulation. Cardiovascular Imaging
|August 26, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for isolation of nuclei from murine cardiac tissue for single-nucleus multiomic sequencing.

STAR protocols·2026
Same author

High-precision aortic banding with O-rings: a versatile model for studying heart failure mechanisms in rats.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

The border zone after myocardial infarction: clarification of terminology and proposal for a new definition.

Cardiovascular research·2026
Same author

Effects of proANP<sub>31-67</sub> in a preclinical model of uninephrectomy and cardiac ischemia/reperfusion injury: cardiac remodeling and tissue biochemical profiling.

American journal of physiology. Cell physiology·2026
Same author

Validation of shear wave elastography for assessing myocardial fibrosis in patients with end-stage heart failure.

European heart journal. Cardiovascular Imaging·2026
Same author

Sacubitril/valsartan preserves kidney function in rats with cardiorenal syndrome after myocardial infarction.

PloS one·2025

Regional work differs between nonfailing and failing hearts after myocardial infarction (MI). Work analysis offers added value over strain analysis alone for understanding heart failure post-MI.

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Mechanics
  • Myocardial Infarction Research

Background:

  • Understanding regional function after myocardial infarction (MI) remains incomplete.
  • Investigating regional myocardial strain and work in post-MI rats is crucial.

Purpose of the Study:

  • To investigate regional myocardial strain and work in post-myocardial infarction (MI) rats.
  • To differentiate between failing and nonfailing hearts post-MI using these metrics.

Main Methods:

  • Utilized cine and phase-contrast magnetic resonance imaging in 62 male Wistar-Hannover rats post-MI and 14 sham-operated rats.
  • Calculated regional strain and work from MRI and left ventricular pressure data.
  • Classified MI rats into nonfailing (MI_NF) and heart failure (MI_CHF) groups based on pressure.
Keywords:
heart failureinfarctionmagnetic resonance imagingmyocardial infarctionrats

More Related Videos

Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

15.5K
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

7.3K

Related Experiment Videos

Last Updated: Feb 24, 2026

Acute Myocardial Infarction in Rats
07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

54.8K
Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

15.5K
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

7.3K

Main Results:

  • MI_NF rats showed preserved strain and increased work in remote regions compared to sham.
  • MI_CHF rats exhibited reduced longitudinal strain and no increased work in remote regions.
  • In noninfarcted adjacent regions, MI_CHF rats had substantially reduced work due to negative work.

Conclusions:

  • Distinct differences in regional work exist between nonfailing and failing hearts post-MI.
  • Work analysis provides novel insights into regional function and heart failure development.
  • Work analysis offers significant added value beyond strain analysis alone.