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Updated: Feb 24, 2026

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research
Published on: March 29, 2024
A candidal oesophageal stricture responsive to fluconazole therapy
1Department of Gastroenterology, Manchester Royal Infirmary, Manchester, UK.
A rare candidal esophageal stricture in an 81-year-old man was successfully treated with prolonged anti-fungal therapy. This approach offers an alternative to traditional esophageal balloon dilation for managing this condition.
Area of Science:
- Gastroenterology
- Mycology
- Internal Medicine
Background:
- Candidal esophageal strictures are uncommon conditions.
- Dysphagia and odynophagia are common symptoms.
Observation:
- An 81-year-old male presented with a 2-year history of gradual onset dysphagia and odynophagia to solids.
- The patient was diagnosed with a candidal esophageal stricture.
Findings:
- Most reported cases of candidal esophageal stricture achieve treatment success with esophageal balloon dilation.
- This study reports the first successful resolution of candidal esophageal stricture using a prolonged course of anti-fungal therapy.
Implications:
- Prolonged anti-fungal therapy is a viable treatment option for candidal esophageal strictures.
- This finding may offer a less invasive alternative to dilation procedures.
- Further research is warranted to establish the efficacy and optimal duration of anti-fungal therapy for this condition.
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