Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Changes in the Appendicular Skeleton with Age

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-Dose Propranolol versus Amitriptyline for Episodic Migraine Prophylaxis: A Randomized Controlled Trial Assessing Efficacy, Safety, and Cost-Effectiveness.

Clinical drug investigation·2025

Same author

Imaging of pulmonary infections encountered in the emergency department in post-COVID 19 era- common, rare and exotic. Bacterial and viral.

Emergency radiology·2024

Same author

Intra-operative drug level monitoring of pre-operative antibiotic for surgical prophylaxis in the patients of elective spinal surgery.

Journal of basic and clinical physiology and pharmacology·2023

Same author

Multimodality imaging review of ulnar nerve pathologies.

The neuroradiology journal·2023

Same author

Gastrointestinal Manifestations of Immunodeficiency: Imaging Spectrum.

Radiographics : a review publication of the Radiological Society of North America, Inc·2022

Same author

Gas Where It Shouldn't Be! Imaging Spectrum of Emphysematous Infections in the Abdomen and Pelvis.

AJR. American journal of roentgenology·2021

Same journal

Orthodontic Extrusion of a Traumatically Intruded and Subsequently Ankylosed Incisor Following Surgical Luxation: A Case Report.

Case reports in pediatrics·2026

Same journal

Severe Late-Onset Vitamin K Deficiency Bleeding Presenting With Subdural Hematoma and Seizures in a 4-Month-Old Infant: A Case Report From a Resource-Limited Setting.

Case reports in pediatrics·2026

Same journal

Nonoperative Management of a Pediatric Blunt Traumatic Distal Tracheal Injury.

Case reports in pediatrics·2026

Same journal

Atypical Presentation of Rapidly Progressive Guillain-Barré Syndrome With Dysautonomia in an Adolescent With Persistent <i>Mycoplasma pneumoniae</i> Infection: A Case Report.

Case reports in pediatrics·2026

Same journal

Neurophysiological Testing is Useful for the Diagnosis and Treatment of Neuropsychiatric Systemic Lupus Erythematosus.

Case reports in pediatrics·2026

Same journal

Bilateral Idiopathic Dacryoadenitis in an Infant: A Case Report and Review of the Literature.

Case reports in pediatrics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 24, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

Split-Hand Malformation in a 4-Year-Old Child.

Girish Gulab Meshram¹, Kanwaljeet Singh Hura², Neeraj Kaur³

¹Department of Pharmacology, Postgraduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India.

Case Reports in Pediatrics

|August 26, 2017

Summary

This summary is machine-generated.

Split-hand deformity, a type of split-hand/split-foot malformation, presented in a 4-year-old child with a lobster-claw appearance. This case highlights a likely de novo mutation causing the congenital limb difference.

More Related Videos

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Block Building Task Identifies Distinct Groups of Left/Right-hand Choice Patterns After Unilateral Peripheral Nerve Injury

Block Building Task Identifies Distinct Groups of Left/Right-hand Choice Patterns After Unilateral Peripheral Nerve Injury

Published on: March 21, 2025

Related Experiment Videos

Last Updated: Feb 24, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

Published on: March 4, 2014

Block Building Task Identifies Distinct Groups of Left/Right-hand Choice Patterns After Unilateral Peripheral Nerve Injury

Block Building Task Identifies Distinct Groups of Left/Right-hand Choice Patterns After Unilateral Peripheral Nerve Injury

Published on: March 21, 2025

Area of Science:

Medical Genetics
Developmental Biology
Orthopedics

Background:

Split-hand/split-foot malformation (SHFM) is a spectrum of congenital limb anomalies.
Split-hand deformity represents a milder end of the SHFM spectrum.
Understanding the genetic basis and clinical presentation of SHFM is crucial for diagnosis and management.

Observation:

A 4-year-old child presented with congenital split-hand malformation of the left hand.
The affected hand exhibited a median cleft with absence of the 3rd and 4th digits.
This resulted in a characteristic "lobster-claw" appearance, with modest functional impairment.

Findings:

The patient's split-hand deformity was characterized by syndactyly and oligodactyly.
No family history of similar limb malformations suggested a de novo mutation.
Genetic counseling was provided to the parents regarding the etiology.

Implications:

This case contributes to the understanding of SHFM phenotypic variability.
Early identification and genetic counseling are important for affected families.
Further research into the genetic underpinnings of de novo mutations in SHFM is warranted.