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Published on: October 31, 2019
Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris
Fan Zhang, Kenneth Barns1, F Michael Hoffmann1
1Small Molecule Screening & Synthesis Facility, UW Carbone Cancer Center , Madison, Wisconsin 53792, United States.
Abstract:
Here we describe the rapid identification and prioritization of novel active marine natural products using an improved dereplication strategy. During the course of our screening of marine natural product libraries, a new cyclic trihydroxamate compound, thalassosamide, was discovered from the α-proteobacterium Thalassospira profundimaris. Its structure was determined by 2D NMR and MS/MS experiments, and the absolute configuration of the lysine-derived units was established by Marfey's analysis, whereas that of C-9, 9', and 9″ was determined via the circular dichroism data of the [Rh2(OCOCF3)4] complex and DFT NMR calculations. Thalassosamide showed moderate in vivo efficacy against Pseudomonas aeruginosa.
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