[Clozapine-induced cholestatic liver lesions. A case study]

Area of Science:

• Hepatology
• Clinical Pharmacology

Background:

• Neuroleptic medications like clozapine are widely used for psychiatric conditions.
• Transaminase elevations are known, but severe liver injury is uncommon.

Observation:

• A 54-year-old woman on clozapine treatment presented with jaundice.
• Clinical examination revealed signs of severe liver damage.

Findings:

• The patient developed cholestasis, a condition where bile flow is obstructed.
• This resulted in severe hepatic parenchymal damage, a serious liver injury.

Implications:

• This case highlights a rare but severe adverse effect of clozapine.
• Clinicians should monitor liver function closely during clozapine therapy.