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[Type II multiple endocrine neoplasms. Diagnosis, therapy and prognosis]
Deutsche Medizinische Wochenschrift (1946)
|June 5, 1987
Summary
Multiple Endocrine Neoplasia (MEN) type II patients require extensive family screening for early disease detection. C-cell carcinoma, pheochromocytoma, or hyperparathyroidism necessitate excluding MEN type II.
Area of Science:
- Endocrinology
- Oncology
- Genetics
Context:
- This study reviewed ten patients diagnosed with Multiple Endocrine Neoplasia (MEN) types IIa and IIb between 1979 and 1986.
- The cohort included nine patients with C-cell carcinoma and one with C-cell hyperplasia, with no instances of hyperparathyroidism.
Purpose:
- To analyze the clinical presentation, treatment, and outcomes of patients with MEN type II.
- To emphasize the importance of comprehensive family screening and differential diagnosis in MEN type II management.
Summary:
- Seven patients had MEN type IIa and three had MEN type IIb. Nine presented with C-cell carcinoma, and six underwent adrenalectomy for pheochromocytoma.
- All patients had total thyroidectomy; three later required neck dissection for metastases. One patient succumbed to metastatic C-cell carcinoma.
Impact:
- Highlights the critical need for early detection through family screening in MEN type II.
- Underscores the necessity of considering MEN type II in patients with C-cell carcinoma, pheochromocytoma, or hyperparathyroidism for accurate diagnosis and treatment.