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Related Experiment Video

Updated: Feb 24, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
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A vitamin D protocol post-liver transplantation.

Cristin Grant1,2

  • 1UCLA Medical Center.

Journal of the American Association of Nurse Practitioners
|August 26, 2017
PubMed
Summary

A vitamin D supplementation protocol effectively increased vitamin D levels in liver transplant patients, potentially reducing complications like graft rejection and infections in this vulnerable population.

Keywords:
25-Hydroxyvitamin Dadvanced practice nursechronic liver diseaseclinical practice guidelinesevidence-based practicenurse practitionerposttransplant

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Area of Science:

  • Hepatology
  • Endocrinology
  • Transplantation Medicine

Background:

  • Adults with compromised liver function are at high risk for vitamin D deficiency.
  • Vitamin D deficiency can exacerbate liver disease, increase infection risk, and lead to graft failure.

Purpose of the Study:

  • To propose and evaluate a vitamin D supplementation protocol for optimizing serum vitamin D levels.
  • To assess the protocol's efficacy in pre- and post-liver transplant patients.

Main Methods:

  • A quasiexperimental study involving 45 post-liver transplant patients.
  • Patients received 2500 units of cholecalciferol (vitamin D3) daily for 12 weeks.
  • Serum 25-hydroxyvitamin D levels were measured pre- and post-intervention.

Main Results:

  • 78% of patients achieved recommended vitamin D levels with the protocol.
  • Average serum vitamin D levels increased by 13.8 ng/mL.
  • The protocol demonstrated effectiveness in raising vitamin D in this patient cohort.

Conclusions:

  • Optimizing vitamin D levels can mitigate complications in liver disease and post-transplant patients.
  • This protocol may decrease graft rejection and infections in immunocompromised individuals.
  • Nurse practitioners can improve patient outcomes, safety, and healthcare economics by implementing this vitamin D protocol.