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Updated: Feb 24, 2026
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Prognostic value of miRNA-181a/b in colorectal cancer: a meta-analysis
Xingwei Gu1, Rong Jin2, Xuping Mao1
1Department of General Surgery, Danyang People's Hospital of Jiangsu Province, Danyang affiliated Hospital of Nantong University, Danyang 213000, PR China.
Aims:
miR-181a and miR-181b have been investigated as prognostic biomarkers of colorectal cancer (CRC). However, there is controversy about the role of miR-181a and miR-181b in predicting CRC prognosis. Therefore, we performed this meta-analysis to evaluate prognostic values of miR-181a and miR-181b in CRC patients.
Materials & Methods:
Studies were systemically searched from publications and analyzed, and 999 CRC cases in nine studies were examined in this meta-analysis.
Results:
Hazard ratio for overall survival of high miR-181a and miR-181b expression in CRC was 1.65. More prominent predictive effects were observed in black people, miR-181b group and small-sample-size group.
Conclusion:
High levels of miR-181a and miR-181b predict poor overall survival in CRC patients. miR-181a and miR-181b are promising biomarkers for CRC prognosis.
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