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Updated: Feb 24, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation

Ying X Gue1, Diana A Gorog2,3,4

  • 1Department of Cardiology, East and North Hertfordshire NHS Trust, Hertfordshire SG1 4AB, UK. y.gue@nhs.net.

International Journal of Molecular Sciences
|August 26, 2017
PubMed

The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has gained increasing attention in recent years as it presents novel ways to prevent and treat existing diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular diseases and clinical outcomes and future directions.

Keywords:
cardiovascularendogenousfibrinolysisplateletsspontaneousthrombolysisthrombosis

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