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Stimuli-Responsive Dipeptide-Protein Hydrogels through Schiff Base Coassembly.

Tingting Yuan1,2, Jinbo Fei1, Youqian Xu1,2

  • 1Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Zhonguancun, Beijing, 100190, China.

Macromolecular Rapid Communications
|August 26, 2017
PubMed
Summary

Researchers developed dynamic Schiff base covalent assembly for stable dipeptide-protein hydrogels. These pH-sensitive hydrogels release proteins and encapsulate various molecules, showing great potential in bioapplications.

Keywords:
Schiff basesdipeptideshydrogelsmolecular assembliesproteins

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Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry
  • Protein Engineering

Background:

  • Conventional covalent conjugations are often irreversible.
  • Dynamic covalent chemistry offers reversible and adaptive material properties.

Purpose of the Study:

  • To develop a simple and efficient dynamic Schiff base covalent assembly for constructing stable and smart dipeptide-protein hydrogels.
  • To investigate the gelation mechanism of diphenylalanine-hemoglobin hydrogels.
  • To explore the potential of these hydrogels in various bioapplications.

Main Methods:

  • Dynamic Schiff base covalent assembly.
  • Gelation process and mechanism investigation using diphenylalanine-hemoglobin hydrogel.
  • pH sensitivity and protein release studies.
  • Encapsulation studies with small molecules, proteins, and nanoparticles.

Main Results:

  • Stable and smart dipeptide-protein hydrogels were successfully constructed under mild conditions.
  • The hydrogels exhibited pH sensitivity, enabling controlled protein release.
  • Released proteins retained their native secondary structures.
  • The hydrogels demonstrated versatile encapsulation capabilities for diverse payloads.

Conclusions:

  • Dynamic Schiff base covalent assembly provides a facile route to advanced dipeptide-protein hydrogels.
  • These adaptive hydrogels offer tunable properties for controlled release and encapsulation.
  • The developed hydrogels hold significant promise for diverse bioapplication.