Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Replicative Cell Senescence

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

Apoptosis

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...

Overview of Cell Death

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Beyond chromatin accessibility: bulk ATAC-seq as an integrative assay to portray genomes and epigenomes.

NAR genomics and bioinformatics·2026

Same author

Cytokine-induced senescence in tumors is based on sustained activation of STAT1- and NFκB-dependent gene regulatory signatures.

GeroScience·2026

Same author

Age-independent and targetable transcription factor networks regulating CD8<sup>+</sup> T cell senescence in aging humans.

Cell reports·2026

Same author

Senescent CD8 T Effector Memory Cells are Functionally Impaired, Enriched in Aging and Disease, and a Barrier to Immunotherapy.

bioRxiv : the preprint server for biology·2025

Same author

Identification of novel gene expression programs in thrombin-stimulated hepatic stellate cells.

Research and practice in thrombosis and haemostasis·2025

Same author

Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuli.

Redox biology·2025

Search research articles

Related Experiment Video

Updated: Feb 24, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

SnapShot: Cellular Senescence in Pathophysiology.

Ricardo Iván Martínez-Zamudio¹, Lucas Robinson¹, Pierre-François Roux¹

¹INSERM, U993, 75015 Paris, France; Equipe Labellisée Fondation ARC pour la recherche sur le cancer, 94803 Villejuif, France; Institut Pasteur, Molecular and Cellular Biology of Cellular Senescence and Age-Related Pathologies Group, Nuclear Organization and Oncogenesis Unit, Department of Cell Biology and Infection, 75015 Paris, France.

|August 26, 2017

Summary

This summary is machine-generated.

Cellular senescence, a key cell fate, plays a vital role in both normal bodily functions and disease development. This review explores its impact on health, aging, and various diseases.

More Related Videos

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Related Experiment Videos

Last Updated: Feb 24, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

Techniques to Induce and Quantify Cellular Senescence

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Area of Science:

Cellular and Molecular Biology
Gerontology
Pathophysiology

Background:

Cellular senescence is a state of irreversible cell cycle arrest.
It is implicated in numerous physiological processes, including development and wound healing.
Dysregulated senescence contributes to aging and age-related diseases.

Purpose of the Study:

To provide an overview of cellular senescence.
To highlight the dual role of senescence in health and disease.
To discuss the implications of senescence in the aging process.

Main Methods:

Literature review and synthesis of current research on cellular senescence.
Analysis of the involvement of senescence in various biological contexts.
Focus on key findings from recent studies.

Main Results:

Cellular senescence is a conserved biological response with context-dependent effects.
Senescence can act as a tumor-suppressive mechanism but also drives aging and chronic diseases.
Understanding senescence pathways is crucial for therapeutic interventions.

Conclusions:

Cellular senescence is a fundamental process with significant implications for healthspan and lifespan.
Targeting senescence pathways offers potential therapeutic strategies for age-related conditions.
Further research is needed to fully elucidate the complex roles of senescence.