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CSF Apolipoprotein E in attempted suicide.

Peter Asellus1, Peter Nordström2, Anna-Lena Nordström2

  • 1Department of Clinical Sciences, Umeå University, Umeå, Sweden.

Journal of Affective Disorders
|August 26, 2017
PubMed
Summary

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Lower levels of Apolipoprotein E (ApoE) in cerebrospinal fluid may indicate irreversible suicide attempts. This finding suggests ApoE may be a biomarker for suicide risk.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Cholesterol metabolism is crucial for neural plasticity.
  • Apolipoprotein E (ApoE) is a key protein in cholesterol metabolism.
  • Both cholesterol and ApoE have been linked to suicidal behavior.

Purpose of the Study:

  • To investigate the relationship between cerebrospinal fluid (CSF) ApoE levels and suicidal behavior severity.
  • To assess if CSF ApoE correlates with the number of prior suicide attempts, method reversibility, and violence of the attempt.

Main Methods:

  • CSF samples were collected from 42 medication-free suicide attempters.
  • Apolipoprotein E (ApoE) and 5-hydroxyindoleacetic acid (5-HIAA) levels were measured.
  • Suicide attempt severity was assessed using the Suicide Intent Scale and Freeman Scale, and method violence was classified.
Keywords:
Apolipoprotein ECholesterolStressSuicide attemptViolence

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Main Results:

  • CSF ApoE levels showed a significant negative correlation with Freeman Reversibility scores.
  • A trend indicated lower CSF ApoE levels in attempters using violent methods.
  • Repeat suicide attempters tended to have higher CSF ApoE levels than first-time attempters.

Conclusions:

  • Lower CSF ApoE levels may be associated with irreversible suicide attempts.
  • Apolipoprotein E in CSF could potentially serve as a biomarker for assessing suicide risk.
  • Further research with larger sample sizes and control groups is warranted.