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Related Experiment Videos

In vitro studies of gallstone dissolution using the scanning electron microscope.

W Burnett, K R Dwyer, C H Kennard

    The Australian and New Zealand Journal of Surgery
    |February 1, 1979
    PubMed
    Summary

    Researchers found an insoluble organic matrix in cholesterol gallstones. Adding heparin dissolved this matrix, enabling complete cholesterol dissolution and enhancing gallstone treatment strategies.

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    Area of Science:

    • Biochemistry
    • Gastroenterology
    • Materials Science

    Background:

    • Cholesterol gallstones are common and difficult to dissolve completely.
    • Existing treatments using chenodeoxycholate and deoxycholate salts are not always fully effective.

    Purpose of the Study:

    • To investigate the composition of undissolved cholesterol gallstones.
    • To identify methods for enhancing gallstone dissolution.

    Main Methods:

    • Scanning electron microscopy was used to examine cholesterol gallstones.
    • Gallstones were treated with chenodeoxycholate and deoxycholate salts.
    • The effect of heparin on gallstone dissolution was assessed.

    Main Results:

    • An insoluble organic matrix, likely a mucopolysaccharide, was identified within cholesterol gallstones.

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  • Heparin treatment effectively dissolved this organic matrix.
  • Heparin addition significantly enhanced the in vitro dissolution of cholesterol gallstones.

    • Conclusions:

    • The insoluble organic matrix is a key factor limiting complete gallstone dissolution.
    • Heparin shows potential as an agent to improve cholesterol gallstone dissolution therapies.