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Published on: March 30, 2018
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Case Study: Rare Case of Mantle Cell Lymphoma With Extranodal Involvement in the Foot
Pauline Fu1, Danielle Mercado2, Vera Malezhik2
1Surgeon, Department of Podiatric Surgery and Medicine, Mount Sinai Beth Israel Medical Center, New York, NY.
Summary
Mantle cell lymphoma (MCL) can relapse in the skin, presenting as non-healing wounds. This case highlights the importance of considering MCL relapse in diabetic patients with unusual skin lesions.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma often affecting extranodal sites.
- Commonly involved extranodal sites include bone marrow, GI tract, Waldeyer's ring, lung, and pleura.
Observation:
- An 80-year-old male with a history of MCL in remission presented with a calf nodule and non-healing toe ulceration post-trauma.
- Initial treatments were unsuccessful, and the lesion worsened.
- Histopathology revealed lymphocytes, confirming MCL relapse.
Findings:
- The patient's pedal skin lesions represented a relapse of Mantle cell lymphoma.
- The presentation mimicked a non-healing diabetic wound, complicating diagnosis.
Implications:
- This case underscores the significance of recognizing pedal manifestations of cutaneous MCL.
- Early consideration of MCL relapse in patients with unusual skin lesions, especially those with a history of lymphoma, is crucial for timely diagnosis and management.
- Accurate diagnosis impacts patient prognosis and treatment strategies for MCL.
