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The role of miR-214 in cardiovascular diseases

Yanfang Zhao1, Murugavel Ponnusamy1, Lei Zhang1

  • 1Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Qingdao 266021, China.

European Journal of Pharmacology
|August 27, 2017
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in heart disease. miR-214 shows promise as a biomarker for diagnosing and treating cardiovascular diseases (CVD), despite its complex roles.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is a global health crisis, necessitating new diagnostic and prognostic biomarkers.
  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression and are involved in cardiac physiological and pathological processes.

Purpose of the Study:

  • To review the multifaceted role of miR-214 in various cardiovascular conditions.
  • To explore miR-214's potential as a diagnostic, prognostic, and therapeutic biomarker for CVD.

Main Methods:

  • Literature review of studies investigating miR-214 in cardiovascular diseases.
  • Analysis of miR-214's expression patterns and functional roles in cardiac pathologies.

Main Results:

  • miR-214 is frequently deregulated in cardiovascular diseases and contributes to their pathogenesis.
  • miR-214 exhibits dual functions, acting differently in various cardiac pathological contexts.
  • Despite its complex roles, miR-214 is recognized as a promising biomarker for CVD.

Conclusions:

  • miR-214 plays a significant role in the development and progression of diverse cardiovascular diseases.
  • Understanding miR-214's dual functions is crucial for its effective clinical application.
  • miR-214 holds considerable potential as a biomarker for cardiovascular disease management.

Keywords:
AngiogenesisCardiac hypertrophyHeart failureIschaemic heart diseasesMiR-214Pulmonary arterial hypertension

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