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Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways

Jianghong Cheng1, Yanhong Zhong1, Shuai Chen1

  • 1School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|August 27, 2017
PubMed
Summary

Growth factor receptor-bound protein 2-associated binding protein 2 (Gab2) drives liver cancer development by activating multiple signaling pathways, including inflammatory signals. Gab2 is a potential therapeutic target for hepatocellular carcinoma (HCC).

Keywords:
HCCIL-6Jak2/Stat3 signaling pathwayknockout mousetherapeutic target

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