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Anaerobic Growth and Maintenance of Mammalian Cell Lines
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Oxygen availability and metabolic reprogramming in cancer.

Hong Xie1,2, M Celeste Simon3,4

  • 1From the Abramson Family Cancer Research Institute and.

The Journal of Biological Chemistry
|August 27, 2017
PubMed
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Cancer cells adapt to low oxygen (hypoxia) by reprogramming metabolism, a key mechanism regulated by hypoxia-inducible factor (HIF). These metabolic changes drive tumor growth and offer new therapeutic targets.

Keywords:
IDHROScancerglucoseglutaminehypoxialipid metabolismmetabolism

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Area of Science:

  • Oncology
  • Cancer Metabolism
  • Molecular Biology

Background:

  • Solid tumors are characterized by hypoxia and altered metabolism.
  • Cancer cell adaptation to low oxygen is crucial for tumor progression.
  • Metabolic reprogramming is a hallmark of cancer, enabling cell plasticity.

Purpose of the Study:

  • To review hypoxia-induced changes in cancer cell metabolism.
  • To focus on the role of hypoxia-inducible factor (HIF) in these metabolic alterations.
  • To highlight the impact of metabolic changes on malignant phenotypes.

Main Methods:

  • Literature review of studies on cancer cell metabolism and hypoxia.
  • Focus on hypoxia-inducible factor (HIF) as a key regulator.
  • Analysis of how metabolic alterations influence cancer progression.

Main Results:

  • Hypoxia triggers significant metabolic reprogramming in cancer cells.
  • Hypoxia-inducible factor (HIF) is a central mediator of these adaptive responses.
  • Altered cancer cell metabolism contributes to enhanced malignant phenotypes.

Conclusions:

  • Metabolic reprogramming under hypoxia is essential for cancer cell survival and growth.
  • HIF-mediated pathways are critical regulators of hypoxia-induced metabolic changes.
  • Understanding these metabolic adaptations provides insights for novel cancer treatment strategies.