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Related Concept Videos

Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Related Experiment Video

Updated: Feb 24, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Gut Microbiota and Atherosclerosis.

Daniel Y Li1, W H Wilson Tang2,3,4,5

  • 1Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Current Atherosclerosis Reports
|August 27, 2017
PubMed
Summary
This summary is machine-generated.

The gut microbiota influences atherosclerosis development through infection, immunity, and metabolites like trimethylamine N-oxide (TMAO). Research is advancing to understand these links for targeted therapies.

Keywords:
AtherosclerosisImmune systemMetabolomicsMicrobiomeShort-chain fatty acidsTrimethylamine N-oxide

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Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
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Area of Science:

  • Microbiology
  • Immunology
  • Metabolic Diseases

Background:

  • The Human Microbiome Project has spurred research into microbiota-mediated health risks.
  • The gut microbiota is increasingly recognized for its significant impact on host health.
  • Understanding the gut microbiota's role in disease is a growing area of scientific inquiry.

Purpose of the Study:

  • To review recent findings on the connection between gut microbiota and atherosclerosis.
  • To explore how infection, immunity, metabolism, and bacterial products contribute to atherosclerosis.
  • To highlight the role of trimethylamine N-oxide (TMAO) as a microbiota-dependent metabolite in atherosclerosis.

Main Methods:

  • Evaluation of current clinical and mechanistic studies.
  • Critical examination of research on TMAO and its link to atherosclerosis.
  • Integration of microbiota profiling advancements to understand functional roles.

Main Results:

  • The gut microbiota plays a multifaceted role in the development and progression of atherosclerosis.
  • Specific bacterial products and metabolites, such as TMAO, are implicated in atherogenesis.
  • Advances in microbiota profiling enable deeper interrogation of the microbiome's functional impact.

Conclusions:

  • The gut microbiota is a key factor in atherosclerosis, involving complex interactions.
  • Trimethylamine N-oxide (TMAO) serves as a significant example of microbiota-derived contributors to atherosclerosis.
  • Translational research aims to leverage these findings for targeted therapeutic strategies against atherosclerosis.