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Related Experiment Video

Updated: Feb 24, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Initial gut microbiota structure affects sensitivity to DSS-induced colitis in a mouse model.

Min Li1, Yanqiu Wu1, Yingxin Hu1

  • 1State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

Science China. Life Sciences
|August 27, 2017
PubMed
Summary

Variations in initial gut microbiota significantly impact dextran sulfate sodium (DSS)-induced colitis outcomes in mice. Understanding baseline gut bacteria is crucial for reproducible research and disease mechanism studies.

Keywords:
DSS-induced colitisinitial gut microbiotamouse model

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • The dextran sulfate sodium (DSS)-induced colitis model is widely used but yields inconsistent results.
  • The gut microbiota's role in DSS-induced colitis necessitates evaluating initial microbial variations.

Purpose of the Study:

  • To investigate the influence of initial gut microbiota composition on DSS-induced colitis outcomes.
  • To identify specific microbial signatures associated with colitis severity and treatment response.

Main Methods:

  • Utilized C57BL/6J mice in three independent trials with DSS treatment.
  • Employed high-throughput 16S rRNA gene sequencing to analyze gut microbiota structure and composition.

Main Results:

  • Significant variations in initial gut microbiota were observed across different mouse batches.
  • Distinct microbial profiles, including increased Akkermansia and decreased Barnesiella, were associated with severe colitis.
  • Gut bacteria exhibited differential responses to DSS treatment across trials.

Conclusions:

  • Initial gut microbiota composition profoundly influences DSS-induced colitis.
  • Consideration of gut microbiota is essential for reproducible results in disease mechanism studies using mouse models.