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Updated: Feb 24, 2026

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Development of bone seeker radiopharmaceuticals by Scandium-47 and estimation of human absorbed dose
Leila Deilami-Nezhad1, Leila Moghaddam-Banaem2, Mahdi Sadeghi3
1Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract:
In this study labeling EDTMP (ethylenediamine tetra(methylene phosphonic acid)) and HEDP (Hydroxyethylidene-1, 1-Diphosphonic Acid) as the carrier ligands with Scandium-47 were investigated. The biokinetics of the bone seeking of labeled ligands with Scandium-47 were assessed by measuring the skeletal absorbed dose and then the mice data extrapolated to human absorbed dose and compared with the 186/188Rhenium-HEDP, 153Samarium-EDTMP dosimetry data estimated by other researchers. Because the availability of 47Sc was limited we performed some preliminary studies using 46Sc.
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