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Hypercalcaemia in Paget's disease of bone
The Australian and New Zealand Journal of Surgery
|February 1, 1979
Summary
The Albright syndrome, linked to Paget's disease and hypercalcemia, is questioned in this study. Further investigation is needed to determine the true cause of hypercalcemia in affected patients.
Area of Science:
- Endocrinology
- Bone Metabolism
Background:
- Albright described a syndrome of hypercalcemia in patients with Paget's disease of bone immobilized after fractures.
- This condition was considered a potential cause of severe hypercalcemia with fatal outcomes.
Observation:
- Two cases of fatal hypercalcemia in patients with Paget's disease are presented.
- Both patients also had parathyroid adenomata, complicating the clinical picture.
Findings:
- The existence of the Albright syndrome as a distinct entity is challenged due to a lack of definitive evidence.
- Hypercalcemia in Paget's disease may stem from other underlying causes, such as parathyroid adenomata.
Implications:
- The findings suggest that hypercalcemia in Paget's disease necessitates a thorough investigation to identify the actual etiology.
- Rethinking the Albright syndrome may lead to more accurate diagnoses and appropriate management strategies for hypercalcemic patients with bone disease.