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Related Experiment Videos

Polymorphic DNA marker on X chromosome and manic depression.

J Mendlewicz, P Simon, S Sevy

    Lancet (London, England)
    |May 30, 1987
    PubMed
    Summary

    Genetic factors contribute to manic depression risk. A study found a linkage between manic depression and coagulation factor IX (F9) gene on the X chromosome, suggesting a specific genetic marker for the disorder.

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    Area of Science:

    • Human Genetics
    • Psychiatric Disorders
    • Molecular Biology

    Background:

    • Heredity plays a significant role in the susceptibility to manic depression (bipolar disorder).
    • Identifying specific genetic loci associated with manic depression is crucial for understanding its etiology.

    Purpose of the Study:

    • To investigate a potential genetic linkage between manic depression and the coagulation factor IX (F9) gene.
    • To determine the chromosomal location and statistical significance of this linkage.

    Main Methods:

    • Analysis of DNA samples from peripheral leucocytes of manic depressive probands and relatives across 10 informative families.
    • Utilized a TaqI polymorphism at the F9 locus on the X chromosome (Xq27).
    • Performed statistical analysis of pedigrees to calculate lod scores and recombination fractions.

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    Main Results:

    • A genetic linkage was demonstrated between manic depression and the F9 locus at Xq27.
    • Statistical analysis yielded a maximum lod score of 3.10 at a recombination fraction of 0.11.
    • This indicates a significant association between the F9 gene region and manic depression.

    Conclusions:

    • The findings demonstrate a genetic linkage between a manic depression susceptibility locus and the F9 gene.
    • This linkage is located in the Xq27 region of the X chromosome.
    • The F9 gene serves as a potential genetic marker for manic depression.