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Association between SNCA rs2736990 polymorphism and Parkinson's disease: a meta-analysis
Jinni Fang1, Binghui Hou1, Hongxin Liu2
1Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Neuroscience Letters
|August 29, 2017
Summary
The SNCA gene
Area of Science:
- Genetics
- Neurodegenerative Diseases
Background:
- The single nucleotide polymorphism (SNP) rs2736990 in the SNCA gene is implicated in idiopathic Parkinson's disease (PD) risk.
- Previous studies on the association between rs2736990 and PD have yielded inconsistent results.
Purpose of the Study:
- To conduct a meta-analysis to precisely estimate the association between the SNCA rs2736990 polymorphism and Parkinson's disease susceptibility.
- To consolidate findings from multiple case-control studies to provide a more robust conclusion.
Main Methods:
- A comprehensive literature search was performed across major databases including PubMed, Embase, EBSCO, CNKI, Google Scholar, and Wanfang up to February 2017.
- Six case-control studies involving 2525 PD cases and 2165 controls were selected based on strict inclusion criteria.
- A pooled analysis was conducted to evaluate the association across various genetic models.
Main Results:
- The meta-analysis revealed a significant association between the rs2736990 polymorphism and PD susceptibility across all tested genetic models.
- Specifically, the T allele and the TT and TC genotypes were found to be significantly associated with a decreased risk of Parkinson's disease (e.g., T vs. C: OR=0.772, P=0.001).
Conclusions:
- The rs2736990 (C/T) polymorphism in the SNCA gene is significantly associated with Parkinson's disease.
- The T allele and specific genotypes (TT, TC) of this polymorphism may confer a protective effect, potentially reducing the risk of developing PD.
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