Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

3.6K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.7K
Overview
84.7K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

9.8K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
9.8K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.2K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.2K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.4K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

7.3K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroprotective Dihydro-β-agarofuran-Type Sesquiterpenes from the Seeds of <i>Euonymus maackii</i>.

Journal of natural products·2019
Same author

Establishment of a human iPSC line (SDQLCHi010-A) from a patient with optic nerve malformation carrying a heterozygous mutation in PAX6 gene.

Stem cell research·2019
Same author

An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene.

Stem cell research·2019
Same author

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity.

Cancer discovery·2019
Same author

Generation of an iPSC line (SDQLCHi015-A) from peripheral blood mononuclear cells of a patient with mental retardation type 15 carrying c.1007_1011del, p.(Ile336fs) in CUL4B gene.

Stem cell research·2019
Same author

Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity.

Fitoterapia·2019

Related Experiment Video

Updated: Feb 24, 2026

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

32.3K

How the biliary tree maintains immune tolerance?

Haiyan Zhang1, Patrick S C Leung2, M Eric Gershwin2

  • 1Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease; 145 Middle Shandong Road, Shanghai 200001, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|August 29, 2017
PubMed
Summary

Cholangiocytes, the biliary tree

Keywords:
Biliary atresiaBiliary treeCholangiocytesImmune tolerancePrimary biliary cholangitisPrimary sclerosing cholangitis

More Related Videos

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

15.0K
Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

7.4K

Related Experiment Videos

Last Updated: Feb 24, 2026

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

32.3K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

15.0K
Determining Bile Duct Density in the Mouse Liver
07:35

Determining Bile Duct Density in the Mouse Liver

Published on: April 30, 2019

7.4K

Area of Science:

  • Liver immunology and biliary tree physiology.
  • Cellular mechanisms of immune homeostasis in the liver.

Background:

  • The liver's unique microenvironment, especially the biliary tree, is crucial for immune homeostasis.
  • Cholangiocytes act as the primary defense of the biliary tree, engaging in diverse immunological functions.

Purpose of the Study:

  • To elucidate the immunological roles of cholangiocytes in maintaining biliary tree tolerance.
  • To explore how dysregulation of cholangiocyte-mediated immunity contributes to cholangiopathies.

Main Methods:

  • Review of literature on cholangiocyte immunology and biliary tree pathobiology.
  • Analysis of signaling pathways, including Toll-like receptors (TLRs) and immune mediators.

Main Results:

  • Cholangiocytes employ TLRs for pathogen defense, express IRAK-M and PPARγ for tolerance, induce leukocyte apoptosis, present antigens, and recruit immune cells via cytokines/chemokines.
  • Breaches in biliary tree immune tolerance lead to diseases like primary biliary cholangitis, primary sclerosing cholangitis, and biliary atresia.

Conclusions:

  • Understanding cholangiocyte immune functions is key to biliary tree health.
  • Insights into biliary immune tolerance can guide the development of therapies for autoimmune biliary diseases.