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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
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Adenosine-Phosphate-Fueled, Temporally Programmed Supramolecular Polymers with Multiple Transient States
Shikha Dhiman1, Ankit Jain1, Mohit Kumar1
1Supramolecular Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) , Jakkur, Bangalore, India 560064.
Journal of the American Chemical Society
|August 29, 2017
Summary
Researchers created a novel fuel-dependent helical assembly for supramolecular polymers. This work demonstrates the first temporally programmed, multistate self-assembly, paving the way for dynamic, life-like materials.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Chemical Engineering
Background:
- Natural systems inspire synthetic supramolecular chemistry.
- Mimicking dissipative biological systems like actin filaments is challenging.
- Controlling self-organization in temporal regimes is key for life-like materials.
Purpose of the Study:
- To develop a fuel-dependent helical assembly for supramolecular polymers.
- To achieve temporally programmable self-assembly.
- To design a multistate transient self-assembly using enzymes and fuel.
Main Methods:
- Utilized fuel-dependent helical assembly of supramolecular polymers.
- Employed enzymes (singularly and in tandem) for chiral reorganization.
- Modulated parameters to control assembly lifetimes and rates.
Main Results:
- Successfully demonstrated a fuel-dependent helical supramolecular polymer assembly.
- Achieved temporally programmable self-assembly.
- Designed a multistate transient self-assembly with controllable dynamics.
Conclusions:
- Reported the first instance of temporally programmed multistate reorganization of self-assembly.
- This work advances the design of dynamic, life-like materials.
- The developed system offers controllable lifetimes and assembly rates.
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