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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Related Experiment Video

Updated: Feb 24, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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Mini-Review on Cachexia-Related miRNA.

Fábio Sousa Nunes1, Daniel Moreira-Gonçalves1, Tiago Henriques-Coelho2

  • 1Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, Porto, Portugal.

Critical Reviews in Eukaryotic Gene Expression
|August 29, 2017
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are explored as potential treatments for cachexia (muscle wasting). This review examines their role in cachexia pathways and their impact on preclinical models, offering hope for new therapeutic strategies.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Cachexia, or muscle wasting, is a complex metabolic syndrome linked to underlying illnesses, causing significant muscle mass loss.
  • This condition affects patient survival, treatment response, and quality of life, with limited therapeutic options due to its complex origins.
  • MicroRNAs (miRNAs) are emerging as key regulators of gene expression and potential therapeutic targets in various diseases.

Purpose of the Study:

  • To investigate the role of microRNAs (miRNAs) in the biochemical pathways of cachexia.
  • To evaluate the impact of miRNA targeting on preclinical cachexia models.
  • To explore the potential of miRNAs as therapeutic targets for cachexia.

Main Methods:

  • Literature review of studies investigating miRNA involvement in cachexia.
  • Analysis of miRNA regulatory mechanisms in muscle wasting pathways.
  • Examination of preclinical data on miRNA-based interventions for cachexia.

Main Results:

  • Evidence suggests miRNAs play a significant role in the molecular mechanisms underlying cachexia.
  • miRNA targeting has demonstrated potential in preclinical models, influencing muscle mass and related pathways.
  • Specific miRNAs may act as biomarkers or therapeutic agents for cachexia.

Conclusions:

  • MicroRNAs are implicated in the pathogenesis of cachexia and represent promising therapeutic targets.
  • Further research into miRNA modulation could lead to novel treatments for muscle wasting conditions.
  • Targeting miRNAs offers a potential strategy to improve outcomes for patients suffering from cachexia.