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Published on: January 13, 2017
Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
Sebastian Götze1, Regine Herbst-Irmer2, Martin Klapper1
1Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI) , Junior Research Group Chemistry of Microbial Communication, Beutenbergstraße 11a, 07745 Jena, Germany.
Abstract:
The class of cyclic lipopeptide natural products consists of compounds with a diverse range of bioactivities. In this study, we elucidated the structure of the cyclic lipopeptide anikasin using X-ray crystallography, analyzed its biosynthetic gene cluster, and investigated its natural role in the interaction between the producer strain Pseudomonas fluorescens HKI0770 and protozoal predators. These results led to the conclusion that anikasin has dual functionality enabling swarming motility and acting as a niche amoebicide, which effectively inhibits the social amoeba Polysphondylium violaceum and protects the producer strain from protozoal grazing.
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