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Improved Outcomes of Kidney Transplantation in Infants (Age < 2 years): A Single-Center Experience

Blanche M Chavers1, Michelle N Rheault1, Arthur J Matas2

  • 1Division of Pediatric Nephrology, University of Minnesota, Minneapolis, MN.

Transplantation
|August 29, 2017
PubMed

Insights

Kidney transplants (KTx) in infants show improved survival and shorter hospital stays over time. Early consideration for KTx is recommended for infants with end-stage renal disease (ESRD).

Area of Science:

  • Pediatric Nephrology
  • Transplant Surgery
  • Renal Medicine

Background:

  • Infants under 2 years with end-stage renal disease (ESRD) face high morbidity and mortality.
  • Kidney transplantation (KTx) is a critical intervention for these young patients.

Purpose of the Study:

  • To evaluate the long-term outcomes of kidney transplantation (KTx) in infants.
  • To analyze trends in survival rates and complications over three decades.

Main Methods:

  • A retrospective analysis of 136 infant kidney transplants performed between 1984 and 2014.
  • Outcomes were compared across three eras: 1984-1993, 1994-2003, and 2004-2014.

Main Results:

  • Initial hospital stay post-transplant decreased by 37% over 30 years.
  • Ten-year death-censored graft survival improved from 60% to 80% between the first and second eras.
  • While acute rejection and CMV incidence remained stable, Epstein-Barr virus diagnoses and post-transplant lymphoproliferative disorder increased in later eras.

Conclusions:

  • Infant kidney transplantation outcomes, including patient and graft survival, have significantly improved since 1984.
  • Earlier consideration for KTx in infants with ESRD is warranted.
  • Ongoing monitoring for viral infections and related complications is crucial.
Abstract

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