Renal function after off-pump versus on-pump coronary artery bypass grafting

Area of Science:

• Cardiovascular Surgery
• Nephrology
• Anesthesiology

Background:

• Renal dysfunction is a significant complication following coronary artery bypass grafting (CABG).
• Off-pump CABG (OPCAB) is theoretically associated with reduced renal impact.
• Assessing renal function markers is crucial for evaluating surgical techniques.

Purpose of the Study:

• To compare renal function between on-pump and off-pump CABG.
• To evaluate creatinine clearance as a marker of renal dysfunction post-CABG.
• To determine if OPCAB offers renal protection compared to conventional CABG.

Main Methods:

• Thirty patients undergoing CABG were randomized into on-pump (n=15) and off-pump (n=15) groups.
• Preoperative and postoperative serum creatinine and creatinine clearance were measured for 4 days.
• Demographic characteristics were similar between the two groups.

Main Results:

• No significant difference in serum creatinine rise between on-pump and off-pump groups on postoperative days 1 and 4.
• No significant difference in the fall of creatinine clearance between the groups on postoperative days 1 and 4.
• Postoperative renal function markers were comparable between the two surgical techniques.

Conclusions:

• Coronary artery bypass surgery technique (on-pump vs. off-pump) does not significantly affect renal function.
• Off-pump CABG does not provide significant protection against postoperative renal dysfunction in low-risk patients.
• Both surgical approaches demonstrate similar outcomes regarding renal function post-CABG.