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Related Experiment Video

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Evaluating tear clearance rate with optical coherence tomography.

Izabela K Garaszczuk1, Maryam Mousavi2, Alejandro Cervino Exposito1

  • 1Department of Optics, Optometry and Vision Sciences, University of Valencia, Spain.

Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association
|August 30, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces tear clearance rate (TCR) measured by optical coherence tomography (OCT) to assess tear film quality. TCR correlates with tear film break-up time, blinking frequency, and tear osmolarity in young adults.

Keywords:
Optical coherence tomographyTear clearanceTear meniscus dynamicsTear meniscus heightTear turnover

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Tear Film Dynamics

Background:

  • The tear film is crucial for ocular surface health.
  • Assessing tear film quality is vital for diagnosing and managing dry eye disease.
  • Current methods for tear film assessment have limitations.

Purpose of the Study:

  • To evaluate the early-phase tear clearance rate (TCR) using anterior segment optical coherence tomography (OCT).
  • To investigate the association between TCR and established clinical measures of tear film quality in young adults.

Main Methods:

  • Tear clearance rate (TCR) was defined as the percentage decrease in inferior tear meniscus height 30 seconds post-saline instillation.
  • Anterior segment OCT dynamically measured tear meniscus height.
  • Fifty young subjects underwent TCR assessment alongside Ocular Surface Disease Index (OSDI) questionnaire, tear film osmolarity, fluorescein tear film break-up time (FBUT), and blinking frequency measurements.

Main Results:

  • The mean TCR was 29±13% at 30 seconds and 36±19% at 60 seconds after saline instillation.
  • Significant correlations were observed between TCR and FBUT (r²=0.319), blinking frequency (r²=0.138), tear film osmolarity (r²=0.133), and age (r²=0.095).

Conclusions:

  • Anterior segment OCT effectively monitors tear meniscus changes and quantifies TCR post-instillation.
  • OCT-derived TCR shows potential as an additional diagnostic tool for evaluating the lacrimal functional unit and tear film health.