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Insulin-like growth factor-1 signaling in cardiac aging

Wang-Soo Lee1, Jaetaek Kim2

  • 1Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|August 30, 2017
PubMed

Insights

Cardiovascular aging is linked to the Insulin-like Growth Factor-1 (IGF-1)/IGF-1 Receptor (IGF-1R) system. Deleting IGF-1R in aged mice hearts may delay age-related cardiac dysfunction.

Area of Science:

  • Cardiovascular research
  • Aging biology
  • Molecular medicine

Background:

  • Cardiovascular disease (CVD) is a primary cause of mortality, with aging as a significant risk factor.
  • The Insulin-like Growth Factor-1 (IGF-1) system, including its receptor (IGF-1R), plays a crucial role in cellular processes and is implicated in cardiac aging and longevity.
  • Cardiac aging involves intrinsic dysfunction and molecular/cellular alterations.

Purpose of the Study:

  • To review the current understanding of the IGF-1/IGF-1R system's role in cardiac aging.
  • To compare the biological effects of IGF-1R and the insulin receptor.
  • To present findings on the impact of cardiomyocyte-specific IGF-1R deletion in aged mice on senescence-associated myocardial pathologies.

Main Methods:

  • Literature review of studies on IGF-1/IGF-1R signaling in cardiac aging.
  • Comparative analysis of IGF-1R and insulin receptor functions.
  • Examination of data from aged knockout mice with cardiomyocyte-specific IGF-1R deletion.

Main Results:

  • The IGF-1/IGF-1R signaling pathway is a key regulator of cardiac aging.
  • IGF-1R and insulin receptor exhibit distinct yet overlapping biological effects.
  • Deletion of IGF-1R in aged cardiomyocytes can mitigate the development of age-related myocardial pathologies.

Conclusions:

  • The IGF-1/IGF-1R system is a critical determinant of cardiac aging.
  • Targeting IGF-1R in cardiomyocytes presents a potential therapeutic strategy for age-related cardiac dysfunction.
  • Further research into the comparative roles of IGF-1R and insulin receptor could yield novel insights into cardiovascular health during aging.

Keywords:
AgingHeartInsulin-like growth factor-1LongevityReceptor

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