[Regional microcirculatory disorders in peritonitis]

Area of Science:

• Physiology
• Pathophysiology
• Pharmacology

Background:

• Peritonitis is associated with significant alterations in regional microcirculation.
• Understanding these microcirculatory changes is crucial for effective treatment.

Purpose of the Study:

• To investigate the microcirculatory alterations in peritonitis.
• To evaluate the potential of alpha-adrenoblockers in managing these alterations.

Main Methods:

• Experimental and clinical investigations were conducted.
• Focused on analyzing regional microcirculation parameters.

Main Results:

• Identified arterial spasm, arteriovenous shunting, intestinal hypoperfusion, and local metabolic disorders in peritonitis.
• Alpha-adrenoblockers demonstrated a directed action on microcirculation.

Conclusions:

• Microcirculatory dysfunction is a key feature of peritonitis.
• Alpha-adrenoblockers, combined with circulating blood volume correction, are recommended for managing peritonitis-induced microcirculatory changes.