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Updated: Feb 9, 2026

A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions
Published on: July 16, 2015
The investigation of interferences in immunoassay
Greg Ward1, Aaron Simpson2, Lyn Boscato3
1Department of Biochemistry, Sullivan Nicolaides Pathology, Bowen Hills, QLD 4006, Australia.
Abstract:
Immunoassay procedures have a wide application in clinical medicine and as such are used throughout clinical biochemistry laboratories both for urgent and routine testing. Clinicians and laboratory personnel are often presented with immunoassay results which are inconsistent with clinical findings. Without a high index of suspicion interferences will often not be suspected. Artifactual results can be due to a range of interferences in immunoassays which can include cross reacting substances, heterophile antibodies, autoantibodies and the high dose hook effect. Further, pre-analytical aspects and certain disease states can influence the potential for interference in immunoassays. Practical solutions for investigation of artifactual results in the setting of the routine clinical laboratory are provided.
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