Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.4K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.4K
Bone Disorders01:29

Bone Disorders

5.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.7K
Fractures: Bone Repair01:27

Fractures: Bone Repair

5.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K
The Bone Matrix01:18

The Bone Matrix

6.0K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
6.0K
The Extracellular Matrix01:29

The Extracellular Matrix

12.7K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Markers of compromised gut epithelial barrier integrity increase during the menopause transition.

The Journal of clinical investigation·2026
Same author

Bacterial specificity of the gut microbiome predicts bone density in primary hyperparathyroidism.

Bone research·2026
Same author

Dietary Microplastics Engage Gut Mechanosensory-Endocrine Signaling to Disrupt Bone Homeostasis.

bioRxiv : the preprint server for biology·2026
Same author

Gender-affirming hormone therapy preserves skeletal maturation in young mice via the gut microbiome.

The Journal of clinical investigation·2024
Same author

A two-cohort study on the association between the gut microbiota and bone density, microarchitecture, and strength.

Frontiers in endocrinology·2023
Same author

Differences in hepatocellular iron metabolism underlie sexual dimorphism in hepatocyte ferroptosis.

Redox biology·2023

Related Experiment Video

Updated: Feb 24, 2026

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.0K

Bone Remodeling and the Microbiome.

Roberto Pacifici1

  • 1Division of Endocrinology, Metabolism and Lipids, Department of Medicine, and Immunology and Molecular Pathogenesis Program, Emory University, Atlanta, Georgia 30322.

Cold Spring Harbor Perspectives in Medicine
|August 30, 2017
PubMed
Summary

The gut microbiome influences immune function and inflammatory diseases. Prebiotics and probiotics show promise in protecting against bone loss and maintaining gut health.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Mammalian exposed surfaces host trillions of microorganisms, forming the microbiome.
  • The gastrointestinal tract's microbiota is crucial for nutrition, metabolism, and immune function.
  • Microbiota composition impacts host immunity and inflammatory disease development.

Purpose of the Study:

  • To review the role of the microbiota in bone homeostasis.
  • To examine the effects of prebiotics and probiotics on bone health.
  • To explore the link between gut microbiota and inflammatory conditions.

Main Methods:

  • Literature review of studies on gut microbiome, bone health, and inflammation.
  • Analysis of research on prebiotic and probiotic interventions.

More Related Videos

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

7.3K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.7K

Related Experiment Videos

Last Updated: Feb 24, 2026

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.0K
Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
08:24

Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry

Published on: March 14, 2020

7.3K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

3.7K
  • Synthesis of evidence regarding microbiota's influence on immune status.

    • Main Results:

    • Gut microbiome composition differs between healthy individuals and those with inflammatory conditions.
    • The gut microbiome plays a significant role in regulating bone homeostasis.
    • Prebiotics and probiotics demonstrate protective effects against bone loss.

    Conclusions:

    • The gut microbiota profoundly affects host immune status and inflammatory disease progression.
    • Interventions like prebiotics and probiotics can positively impact bone health.
    • Further research is warranted to fully elucidate the therapeutic potential of modulating the gut microbiome.