Cortical Functional Connections and Fluid Intelligence in Adolescent APOE ε4 Carriers
1School of Exercise and Sport Science, University of Ulsan, Ulsan, South Korea.
Aims:
This study examined differences in corticocortical communication between adolescent ε4 carriers (ε4+) and noncarriers (ε4-) during a fluid intelligence task (Comprehensive Test of Nonverbal Intelligence [CTONI]).
Methods:
Sixteen ε4+ and 20 ε4- individuals aged 13-15 years performed the CTONI while real-time EEG signals were acquired. Inter- and intrahemispheric coherences were analyzed.
Results:
The ε4+ subjects exhibited lower inter- and intrahemispheric coherences than the ε4- individuals.
Conclusion:
ε4 carriers have lower corticocortical communication than noncarriers during an intelligence task, implying that carrying the ε4 allele may reduce brain networking in adolescence, several decades before the onset of Alzheimer disease.
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