Related Experiment Video
Updated: Feb 23, 2026
09:45
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
10.8K
Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory Processing
Swananda Marathe1, Muriel Jaquet2, Jean-Marie Annoni1,3
1Department of Medicine, University of FribourgFribourg, Switzerland.
Frontiers in Cellular Neuroscience
|August 30, 2017
Summary
Reduced Jagged1 levels in Alzheimer
Area of Science:
- Neuroscience
- Cellular signaling
Background:
- Notch signaling is crucial for memory formation.
- Notch1 activity is reduced in Alzheimer's disease (AD) brains.
Purpose of the Study:
- To investigate Jagged1 expression changes in AD.
- To determine if Jagged1 loss causes memory deficits.
Main Methods:
- Analyzed Jagged1 expression in AD brain tissue and cerebrospinal fluid (CSF).
- Utilized a transgenic mouse model with targeted Jagged1 loss in adult neurons.
Main Results:
- Jagged1 expression was reduced in hippocampal CA fields of AD patients.
- Cerebrospinal fluid Jagged1 levels decreased with dementia progression.
- Adult-onset Jagged1 loss in mice induced spatial memory impairment.
Conclusions:
- Jagged1, a Notch ligand, is vital for memory formation.
- Reduced Jagged1 may contribute to memory loss in Alzheimer's disease.
More Related Videos
Related Concept Videos
01:26Alzheimer's Disease: Overview
1.8K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.8K
01:22Alzheimer's Disease: Treatment
1.1K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.1K
01:16Role of Amygdala in Memory
1.3K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
1.3K
01:19Role of Hippocampus in Memory
1.7K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.7K
01:14Role of Cerebellum and Prefrontal Cortex in Memory
1.3K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.3K
03:03Amyloid Fibrils
6.8K
6.8K