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Rifaximin for Pertuzumab-Related GI Toxicities
Aixa E Soyano1, Gina Reynolds1, Alvaro Moreno-Aspitia1
1Robert and Monica Jacoby Center for Breast Health, Mayo Clinic, Jacksonville, FL, United States.
Abstract:
Pertuzumab is a monoclonal antibody against HER2. Diarrhea and abdominal pain are common adverse events of pertuzumab-based therapy, occurring in almost 70% of patients. The incidence of gastrointestinal toxicities intensifies when pertuzumab is given in combination with chemotherapy. Rifaximin, a non-absorbable oral antibiotic, may provide symptomatic relief in patients with refractory gastrointestinal toxicities from pertuzumab-based therapy beyond standard routine antidiarrheal medications. We present a case of HER2-related therapy-induced diarrhea and abdominal pain managed successfully with Rifaximin.
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