Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory mediator receptors and asthma.

P J Barnes

    The American Review of Respiratory Disease
    |June 1, 1987
    PubMed
    Summary

    Asthma involves many inflammatory mediators acting on cell surface receptors, causing airway constriction and inflammation. While receptor antagonists exist, their broad clinical effect is limited due to the complex nature of asthma pathology.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Glucocorticoid resistance in asthma.

    American journal of respiratory and critical care medicine·1995
    Same author

    Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma.

    The Journal of experimental medicine·1995
    Same author

    Inhibition of macrophage inflammatory protein-1 alpha expression by IL-10. Differential sensitivities in human blood monocytes and alveolar macrophages.

    Journal of immunology (Baltimore, Md. : 1950)·1995
    Same author

    Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

    Molecular pharmacology·1995
    Same author

    Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages.

    The American journal of physiology·1995
    Same author

    Cytokine expression in normal, atopic, and asthmatic subjects using the combination of sputum induction and the polymerase chain reaction.

    Thorax·1995

    Area of Science:

    • Immunology
    • Pharmacology
    • Respiratory Medicine

    Background:

    • Asthma pathogenesis involves numerous inflammatory mediators like histamine and leukotrienes.
    • These mediators exert effects via specific cell surface receptors on various cells.
    • Receptor activation triggers responses such as airway smooth muscle contraction and inflammation.

    Purpose of the Study:

    • To review the role of inflammatory mediator receptors in asthma.
    • To discuss the signaling pathways involved in receptor activation.
    • To evaluate the potential of receptor antagonists in asthma treatment.

    Main Methods:

    • Functional characterization of mediator receptors.
    • Direct receptor binding techniques to identify receptor subtypes.
    • Review of existing literature on mediator-receptor interactions in asthma.

    Main Results:

    • Mediator receptors activate signaling pathways, including adenylate cyclase modulation and phosphoinositide breakdown.
    • Intracellular calcium release is a predominant mechanism, especially in airway smooth muscle.
    • Several receptor subtypes have been identified, and antagonists developed.

    Conclusions:

    • The complexity of asthma, involving multiple mediators, limits the broad clinical efficacy of single receptor antagonists.
    • Platelet-activating factor may increase bronchial responsiveness, suggesting potential benefit from its specific antagonists.
    • Targeting specific mediator pathways may offer a more nuanced approach to asthma management.

    Related Experiment Videos